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A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

Medium-chain fatty acids may play a central role in the KD, which may regulate mitochondrial metabolism in astrocytes and have positive effects on the brain such as accelerated glycolysis, enhanced lactate shuttle, and accelerated ketone body production (190)

Previous studies have indicated that the activation of Akt/GSK3 signaling pathway plays a role in UA-mediated neuroprotection in PD and ALS models [136, 171]

Vigor 01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging

One might hypothesize that, by exchanging the ancestral -type TrxR enzymes for the metazoan version, the evolutionary capacity of the lineage might have been potentiated