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For example, in certain lung pathophysiological conditions, oxygenation of terminal airways becomes uneven, such that this temporal and spatial variance in oxygen abundance essentially determines the survival of the lung cells via oxygen-dependent activation of cell regulators and genes critical to defending their structural/functional characteristics [5, 8, 10, 13, 14, 1618, 2123, 26, 27]

For example, more studies need to be conducted to explore the differences in m 6 A methylation sites in SLC7A11 mRNAs under different conditions, and these marks deposited on different sequence may lead to different fates of mRNAs after being recognized by different readers

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Iron chelator Deferasirox (DFX) has been proved to reduce the iron content of cardiac tissue in HF, thereby playing a role in cardiac protection

The mPTP opens in response to calcium and/or oxidative stress and allows transit of molecules of up to 1,500 Da from inside mitochondria to the cytosol