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In 1996, a research team at the University of Pennsylvania (Hershey, PA, USA) first identified the Kisspeptin gene (KISS1 - named after the most famous local product Hersheys Kisses) for its anti-metastatic properties in malignant melanoma

The belief that co-formulation with hyaluronidase increases the bioavailability of SC drugs appears to be mainly based on the mechanism of action of hyaluronidase rather than robust clinical data