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LT in larger laboratory animals such as dogs and pigs is technically easier

However, the mechanism by which NQO1 mediates these functions is not yet well understood

von Lueder TG, Gravning J, How OJ, Vinge LE, Ahmed MS, Krobert KA, et al

For instance, L-Gln antagonists like acivicin, 6-Diazo-5-oxo-L-norleucine (DON), and azaserine caused significant gastrointestinal side effects and neurotoxicity