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Using transcriptomics, histopathological and western blot analyses, the liver fibrosis markers previously found after 24 weeks on this diet include a significant upregulation of pathways/genes related to fibrogenesis and ECM remodelling ( Col1a1 , Col1a2 , Col3a1 , Col4a1 , Col4a2 , Timp1 and Serpine1 ), TGF ( Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 and Tgfbr2 ) and SMAD signalling (SMAD2 Ser 465/467 phosphorylation), as well as perisinusoidal and portal fibrosis 12,32,33,34

Table 1 provides demographics of the participants who underwent each treatment

PMID 15947480

AOD 9604 Purpose: A modified fragment of human growth hormone designed to stimulate fat metabolism

Therefore, it is difficulty to explore targeted inhibitors because of the partially ambiguous mechanism of ferroptosis, and it is likely that developing a single inhibitor will not achieve high efficacy