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M.BgenholmR.ThoresenM

This is thought to occur through modulation of key signaling pathways like NF-B

And the weight loss curve had not yet plateaued, meaning participants were likely to lose even more with continued treatment

Regardless of deterministic or stochastic concepts of aging, it is still poorly understood if protective variants have specifically evolved at the FOXO3 locus because of unique features of the FOXO3 isoform or because FOXO3 is predominantly expressed in relevant tissues