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Compared to those of control cells, Igf1 mRNA levels were significantly higher in LCs treated with 10 g/L (0.03 IU/L) rhGH but significantly lower in LCs treated with 50 g/L (0.15 IU/L) rhGH

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Vascular endothelial growth factor (VEGF) is a key mediator of this process, and studies have shown that CSCs often overexpress VEGF, ensuring that the growing tumor receives enough oxygen and nutrients