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1 Introduction Multiple myeloma (MM), a hematologic malignancy characterized by clonal proliferation of bone marrow plasma cells, manifests clinically through CRAB criteria: hypercalcemia, renal dysfunction, anemia, and osteolytic lesions ( Ferroptosis, an iron-dependent non-apoptotic cell death driven by excessive lipid peroxidation, was first characterized by Dixon et al., in 2012 through studies on erastin and RAS-selective lethal compounds (Zhang et al., 2022

Even more rarely, persistent eye twitching may be a sign of an underlying neurological condition such as: The main symptom of myokymia is an eyelid that twitches uncontrollably

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In the PI3K/AKT pathway, the DEGs focused on the integrin-related downstream signaling (Fig

Moreover, QUE triggered lysosomal activation by promoting the nuclear translocation of EB and activating the transcription of lysosomal genes