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The role of the IGF1-Akt pathway in adult skeletal muscle There is no doubt that IGF1 is a major regulator of muscle mass during development, thanks to its effect on myogenic cell proliferation and differentiation [103]

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Cannabinoid receptors are also activated by endogenous ligands, the en-docannabinoids, a family of endogenous arachidonic acid derivatives, including N-arachidonylethanolamide (anandamide) and the 2-arachidonoylglycerol which is synthesized by the cell membrane (Sugiura et al., 2002)