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Question So, I uploaded my 23andMe raw data to NutraHacker and their recommendation, based on heterozygous mutation of the COMT genes, was to avoid methyl groups and substitute instead with hydrocobalamin

Mood-related symptoms of B12 deficiency include persistent irritability, low mood or emotional flatness that doesn't respond to typical coping strategies, restlessness, difficulty concentrating, and a general sense of being "off" that's hard to articulate

Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients

What does not adjust is guessing

The 21-28 day recommendation accounts for this additional degradation pathway