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In the last decade, studies on the condition of BBB in neurodegenerative diseases, including ALS, have demonstrated the presence of vascular disruption, a condition that could theoretically favour the entry of drugs into brain regions affected by neurodegeneration

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Samples were then mixed in a 50:50 with washed 5% RBC solution and incubated for 30 minutes at 37C stationary in round-bottom 96-well plates

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