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Liu X, Cai Y, Zhang Y, et al

this is the case for mice with podocyte-specific heterozygous INSR deletion (Madhusudhan et al., 2015)

737 Under conditions of low glutamine availability, the transcription factor p53 plays a crucial role in prosurvival signaling by stimulating the expression of transporters to increase the uptake of other amino acids, thereby assisting cancer cells in overcoming nutrient scarcity

Healthcare professionals should actively enquire about complementary therapy use and provide clear, non-judgemental education about evidence-based alternatives that offer genuine therapeutic benefit without unnecessary risk

doi: 10.1016/S0140-6736(23)01419-8 11 BlauwendraatC.HeilbronK.VallergaC