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Molecular Cancer Research

159 The notable abnormalities in host metabolism diminish nutrient and oxygen availability within the TME and lead to the accumulation of metabolic byproducts, which undoubtedly pose additional threats to cellular health and function

FIGURE 1 2 Trimethylamine N-oxide and chronic kidney disease 2.1 Trimethylamine N-oxide is a risk factor for chronic kidney disease Risk factors for chronic kidney disease are various, including disease factors (Diabetes, hypertension, autoimmune diseases, systemic infections, urinary tract infections, acute kidney injury, etc.), Sociodemographic factors (age, gender, ethnicity, and family history of CKD, etc.), and lifestyle factor (smoking, heavy alcohol use, obesity, etc.) (Taal and Brenner, 2008

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