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Eur J Biochem 271(11):21372143

Hazanchuk V

Jihong Liu and Kai Cui: Conceptualization, Supervision, Funding Acquisition, Writing - Review & Editing

Upon encountering DSBs, NHEJ is initiated by the binding of the Ku70/80 heterodimer to the free DNA ends, facilitating the assembly of essential NHEJ components such as DNA-dependent protein kinase catalytic subunit (DNA-PKcs), X-ray repair cross-complementing protein 4 (XRCC4), and DNA ligase IV (LIG4)