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Protocol approach: frozen shoulder (adhesive capsulitis) Goal: Reduce capsular fibrosis, restore range of motion, manage pain Peptide approach: BPC-157: 300 to 500 mcg daily for anti-inflammatory and tissue healing properties TB-500: 500 to 750 mcg twice weekly for systemic anti-inflammatory and tissue remodeling Note on relaxin-2: While the most specifically targeted peptide for this condition, it remains largely in the research phase and is not widely available through standard channels Duration: Twelve to sixteen weeks (frozen shoulder has a prolonged natural course) Critical addition: Aggressive physical therapy within pain tolerance

Per BNF and BSH guidance: For confirmed deficiency without neurological involvement: 1 mg IM on alternate days for two weeks, then 1 mg every two to three months for maintenance

doi: 10.3389/fnut.2023.1068343 Received 12 October 2022 Accepted 21 March 2023 Published 05 April 2023 Volume 10 - 2023 Edited by Andrew Scholey, Monash University, Australia Reviewed by Jessica Zuiga-Hernandez, University of Talca, Chile

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High levels of dopamine metabolism, iron, and calcium, coupled with mitochondrial dysfunction and neuroinflammation, contribute to the excessive production of ROS in the brains of PD patients (183)