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178,179,180 In 2004, the FDA approved the first aptamer drug, pegaptanib (Macugen), to treat choroidal neovascularization caused by neovascular age-related macular degeneration (AMD)

10.1016/j.phymed.2018.09.199 111 JiangZ.ZhouY

Slight et al

Histological assessments showed that Lv-siPDE5-ADSC treatment resulted in higher smooth muscle content and improved cavernous tissue recovery, with significantly enhanced smooth muscle/collagen ratios compared to unmodified ADSCs