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Renal fibrosis-associated genes were retrieved from the gene cards database (relevance score 20) using different keywords: kidney fibrosis (1), chronic kidney diseases (1707), aZend-stage renal failure (719), and nine genes were retrieved from the TTD database

The accumulation of Kyn may be a result of decreased catabolism by Kyn hydroxylase owing to NADPH dependence of this enzyme (Breton et al

However, protein biomarkers arent appropriate options for early diagnosis in terms of their low specificity and their likelihood to be phenotype-specific [7]

Chronic illness can impair liver detoxification, leading to toxin buildup, oxidative stress, and severe fatigue

van Lingen RA, Deinum JT, Quak JM et al , Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates