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Mitochondrial fusion is primarily regulated by mitofusin-1/2 (MFN1/2) and optic atrophy 1 (OPA1), while mitochondrial fission is mainly controlled by dynamin-related protein 1 (DRP1) (see Figure 3 ) (143146)

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However, in 2006, gadolinium-containing contrast agents were first mentioned as a cause of Nephrogenic Systemic Fibrosis [5,6]