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The use of peptide therapies should prioritize evidence-based decision-making where available, careful evaluation of risks and benefits, appropriate regulatory alignment, and ongoing attention to emerging safety data (Petrou et al., 2025)

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Among these methods, disulfide trapping offers distinct advantages: it minimizes non-specific artifacts compared to chemical cross-linking and has a lower risk of disrupting protein folding or expression compared to genetic fusion approaches

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In two controlled trials of 6 to 8 weeks duration where the ability of patients to discontinue medication was measured, 7 to 29% of patients treated with alprazolam did not completely taper off therapy