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in 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society 19691972 (IEEE, 2011)

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While orchidectomy (ORX), OVX, or anti-androgen treatment during sensitive growth periods or milestones in the lifespan would confirm a causal relationship between changes in circulating androgens, not tissue-specific AR, as the driving force of sex differences in the outcomes measured, there are considerable caveats to these methods as well

143,144 This may be due to UV-induced suppression of the immune system or direct reactivation of the virus