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Abstract Reactive oxygen species (ROS) are context-dependent mediators that function as second messengers at low, localized flux and as drivers of damage when production overruns buffering capacity

Jednoczenie interpretacja wynikw powinna uwzgldnia eksperymentalny charakter tej czsteczki oraz rnice midzy modelami in vitro, przedklinicznymi i zastosowaniami translacyjnymi

Additionally, the heat stress marker hsp-16.2 was consistently downregulated with the glucose-fed bacterial diet as determined by both GFP fluorescence and mRNA expression (Supplementary Figures S3a and S3b)

Strong correlations were observed for intestinal and kidney models ( r = 0.99), with slightly lower correlation in liver models (r = 0.96), indicating minimal divergence and supporting their use for downstream PK/PD studies (Supplementary Fig