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The homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 2 (HERPUD1) in cultured HELA cells facilitate cytoprotective effects against oxidative stress by suppressing the inositol 1,4,5-triphosphate receptor and reducing the transfer of calcium ions from the endoplasmic reticulum to mitochondria [41]

In addition, Li et al

291,292,293 Heterochromatin region in young cells and organisms silences reversible transposable factors, but due to the lack of regulation of higher-order chromatin structure, they are activated in the context of cell senescence and tissue ageing