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Moayyedi P, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al

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Yue-Yu Gu, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The time taken by the mice to reach the floor with its four paws was recorded as locomotion activity time T-total and the time taken by the mice to turn completely head downward was recorded T-turn time