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Expression of Fas and FasL depends on the stage of erythropoiesis, which allows regulating expansion of cells via inducing apoptosis of Fas-expressing immature erythroblasts by FasL-expressing mature erythroblasts [98]

doi: 10.1016/S0928-4257(99)00119-9

Since ED is a common comorbidity in this group and patients often avoid reporting it actively due to a sense of shame, all male patients with genital involvement, high disease activity, or subjective reports of decreased QoL should be included in the systematic assessment

Another detailed aspect of combination therapy involves the use of TGF- inhibitors alongside agents targeting other key signaling pathways implicated in fibrosis, such as the Wnt/-catenin or PI3K/Akt pathways (128)

PubMed , European Journal of Endocrinology , vol