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Oxidative stress is closely linked to the development and progression of DR

Glutamine skipping the Q into mitochondria

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Several independent lines of evidence thus suggest that oncogenic KRAS G12D and G12V lead to a higher expression of nuclear FOXO1, which in turn results in increased glutamine synthesis, ammonia detoxification via glutamine synthetase upregulation, and amino acid synthesis via transamination reactions in G12D

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