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Glycemic mechanism and insulin sparing sensitization not secretion: fasting insulin and C-peptide fall while insulin sensitivity (HOMA2-%S) rises +31.8/+43.2/+49.9% (SURPASS J-mono, Hamamoto 2025)

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Experimental studies further demonstrate that A oligomers directly inhibit long-term potentiation and memory formation, highlighting synapses as critical early therapeutic targets ( Targeting synapses remains challenging due to their highly compartmentalized structure and dynamic regulation across complex neuronal networks

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