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effective treatment to eliminate Demodex bacteria causing seborrheic dermatitis

Microneedling typically uses solid needles that create channels without active serum delivery

This was then employed as a template for the generation of all mutant forms, which were obtained through overlap PCR with individual primers pairs (Supplementary Table 2)

The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment