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Multiple enzymatic components (mRNA, proteins, activities) of this pathway are upregulated in dwarf mice including methionine adenosyltransferase (Mat), glycine N-methyltransferase (Gnmt), S-adenosylhomocysteine hydrolase (Ahcy), cystathionine -synthase (Cbs), and cystathionine -lyase (Cth) [2426]