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Immuno-scanning electron microscopy has revealed these as approximately 1:1 PNC-27:HDM-2 complexes arranged in layered ring-shaped structures within transmembrane pores near the cell surface

Twenty-two patients were enrolled in the study and were assigned to one of five cohorts receiving a single IV infusion of pegadricase (0.1, 0.2, 0.4, 0.8, or 1.2 mg/kg) (Supplementary Figure 1)