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Further, a neurotransmitter deficiency state including the elevation of GABA (gamma-amino-benzoic acid), PEA (phenyl-ethyl-amine), and histamine, and more generally any abnormal alteration of excitatory or inhibitory neurotransmitters that result in a disease state

doi: 10.1016/j.freeradbiomed.2024.07.007 15 AkaikeTIdaTWeiFYNishidaMKumagaiYAlamMMet al

Common Side Effects Facial flushing or warmth Nausea, stomach discomfort Chest tightness or pressure (usually dose/rate dependent) Headache Fatigue after administration Injection site discomfort, redness, or swelling Mild dizziness Seek Medical Attention For Severe chest pain or difficulty breathing Signs of allergic reaction: hives, facial swelling, throat tightness Fainting or severe dizziness Use in Pregnancy and Breastfeeding The safety of NAD+ therapy during pregnancy and breastfeeding has not been established

Reciprocally, cGAS-STING pathway members can actively induce canonical as well as various non-canonical forms of autophagy, establishing a regulatory network of feedback mechanisms that alter both the cGAS-STING and the autophagic pathway

doi: 10.1021/jm501506f 153 NairzM.SchrollA.HaschkaD.DichtlS.TymoszukP.DemetzE.et al