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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

The apoptotic cells were observed after 3 days culture in both groups

Since you will have likely had an inflammatory process in your body for almost a decade at this point, you will need to take on the most aggressive treatment

And the doctor who prescribed it would refute the lack of data, saying the absence of evidence is not evidence of absence, and that his patients are deriving substantial benefit without side effects

in Methods in enzymology Vol