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Furthermore, sphingolipid metabolism presents promising therapeutic targets, including the depletion of GSLs and modulation of S1P-metabolizing enzymes (Dodge et al., 2015

Simultaneously, Akt activation suppresses the ubiquitin proteasome system through inhibition of FoxO-mediated transcription of E3 ubiquitin ligases (MAFbx/Atrogin-1, MuRF1), which are responsible for protein degradation

Maintaining healthy antioxidant status supports overall cellular wellness and helps protect tissues from oxidative stress

Evaluate patients for respiratory depression and sedation at frequent intervals

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