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Peptides from the TDP-43's putative amyloidogenic core region (aa 286366) containing the ALS-associated mutations were also found to efficiently form amyloid-like fibrils (Chen et al., 2010

Mechanistic Comparison# Dosing Comparison# Amycretin Dosing# Amycretin dosing is investigational: Subcutaneous: Once-weekly injection, doses up to 60 mg studied in phase 1b/2a over 36 weeks Oral: Daily tablet, doses up to 50 mg (or 2 x 50 mg) studied in phase 1 Phase 2 T2D: Both subcutaneous and oral formulations studied over 36 weeks Phase 3 dose selection will be informed by the completed phase 2 data

Lee SY, Koo YJ, Lee DH (2021) Classification of endometriosis

This sudden surge of neurotransmitters overwhelms the receptors on the stem cells, triggering their immediate and disordered activation