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It becomes more difficult to exercise and stick to a diet plan

With increased understanding of toxicity and exposure mechanisms, the model has been updated (McGrath et al., 2018)

The deficiency causes a reduction in red blood cell production, which results in anemia and a reduced oxygen supply to tissues and organs

Path B initially involves displacement of the water molecule, followed by the formation of an LF-type intermediate, which possesses a very shallow energy minimum with respect to the CoC coordinate