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Consistent with the biological changes, immunoblotting analysis showed the late induction of p-H2AX and H2AX [45], suppression of ataxia telangiectasia mutated (ATM) [46] and pS1981-ATM, pT68-Chk2 (checkpoint kinase 2 serine/threonine kinase) [47], rap1 interacting factor (RIF)1 [48], Cdc25C [49], and Cyclin D1, and the induction of p21, CDK1, pS133-Cyclin B1 and Cyclin B1 (Fig

Thus, in combination with functional magnetic resonance imaging techniques, neurochemical mapping may provide the link between functional and metabolic networks across the brain, as well as their impairment in diabetes