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Such compartmentalized receptor engagement and intracellular processing may contribute to sustained or qualitatively altered activation states that support long-term innate immune reprogramming, which remain to be experimentally determined

However, for some patients, the Whipple procedure may extend life and potentially cure the cancer

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Under normal conditions, Nrf2 binds to Keap1 in the cytoplasm and is degraded by the cullin3 (Cul3) complex