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Statements Author contributions XL and LS contributed to conception and design of the study

Correct Coding: ICD-10 Code: E55.9 Vitamin D Deficiency, Unspecified CPT Code: 82306 Vitamin D

Research Summary 5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue and linked to obesity and metabolic dysfunction

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Together, these studies demonstrate that existing injury in the brain increases an individuals risk for further and/or prolonged injury with infection and other diseases that are do not directly impact the CNS