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Nature 261:166-168

Irrespective of the proposed therapeutic method, it is essential that individuals suffering from L-C19 be included in rehabilitation programs to identify physical, emotional, cognitive and social treatable traits

3,5-diCQM drives melanogenesis in a dose-dependent manner, and the molecular mechanism underlying its ability to induce pigmentation is through activation of the p38 signaling pathway, phosphorylation and activation of CREB, and a cAMP/PKA dependent signaling pathway, which in turn upregulates the transcription factor MITF, thereby activating tyrosinase activity (Kim et al., 2015)

(PubMed) Mangiapane E, Pessione A, Pessione E

In addition, reported outcomes differ from trial to trial, preventing rigorous evidence synthesis, for example in forms of well-conducted meta-analyses