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Oral vitamin B12 is generally safe to take at recommended doses

Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing)

Patients on long-term PPIs should have their B12 status monitored periodically, particularly if other risk factors are present

Figure 1: Changes in gross morphological scores amongst the four experimental treatment groups

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