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This review delves into the intricacies of these interactions, particularly in the context of stroke, diabetes, and systemic inflammation (Figure 2)

Mitsumoto H, Santella RM, Liu X, Bogdanov M, Zipprich J, Wu HC et al

Increased BDI-II scores resulted from items related to mental and physical fatigue (tiredness/fatigue, loss of energy, items referring to cognitive symptoms such as concentration difficulties) apart from one patient, who had a higher score across most items, while still not meeting the criteria for depression

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Immune defense is the ability of cells (such as neutrophils and macrophages) and molecules in the lungs to clear pathogens from the alveoli and prevent them from entering the bloodstream (Hiroki et al., 2021)