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identified a small chemical compound, erastin, by using synthetic lethal high-throughput screening, which can cause selectively toxic to cancer cells expressing oncogenic RAS, but not wild-type cells in a manner different from traditional apoptosis (Yang and Stockwell, 2008)

The accumulation of lipid droplets, rich in polyunsaturated fatty acids (PUFAs), also creates vulnerability to ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation [18, 19]

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