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Pruritus characteristic of cirrhosis predominantly manifests as a central phenomenon, purportedly stemming from augmented release of -endorphin, Met-enkephalin, and endomorphin-1,2, which stimulate -receptors within nerve tissues

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Western blot We used the NuPAGE electrophoresis and buffer system (Invitrogen) for immunoblot analysis of kidney samples or cellular lysates as described 48,49

As a dietary supplement, take 1 capsule daily with 8-12 oz of water or as directed by your healthcare provider

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