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Next, we discuss treatments in development that aim to overcome these barriers, including novel drug designs such as nanoparticles and antibodydrug conjugates, novel methods of drug delivery, including convection-enhanced and intra-arterial delivery, and novel methods to enhance drug penetration, such as bloodbrain barrier disruption by focused ultrasound and laser interstitial thermal therapy

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Use of in vivo expression technology for the identification of putative host adaptation factors of the Lyme disease spirochete