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Natalizumab is used to treat multiple sclerosis patients

This occurs because the H-atom of the tertiary carbon is acidic and susceptible to removal by a base to create a nucleophilic carbanion that undergoes reaction with UDP-glucuronic acid (UDPGA) (Figure 5.21c)

10.1039/c8bm01525b Biomater

Professionals believe there is a link between free radicals accumulation, glutathione status and reactive oxygen species

5-(3-bromo-d5-propylidene)-5H-dibenzo[a,d]cycloheptene (from EXAMPLE 5) and 3-fluoro-pentadeutero-azetidine, deuterochloride salt (from EXAMPLE 6) are combined using the procedure in EXAMPLE 4 to make 1-(3-Dibenzo[a,d]cyclohepten-5-ylidene-d5-propyl)-3-fluoro-pentadeutero-azetidine