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First, the CTD adopts the Apo conformation indicative of an enzyme without bound substrates, while the second conformation is structurally distinct from the canonical conformations observed previously (Fig

Moreover, another antifungal agent, clotrimazole, can inhibit cancer cell division and proliferation by blocking the entry of calcium and potassium ions into the cells ( The third-generation EGFR inhibitor osimertinib (OSI) has a dual function