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Under conditions of hypoxia, nutrient deprivation, or impaired mitochondrial function, cancer cells modulate NADPH and GSH levels through key metabolic pathways such as the pentose phosphate pathway (PPP), FAO, and glutamine metabolism, thereby establishing a metabolicredox feedback loop [39,40,41]

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Promoter hypermethylation at MEST locus by ZFP57 was shown to be lost in breast cancer which led to enhanced Wnt signaling (Hahn et al., 2013

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Some protocols use site-specific injections near the injury for more localized effects, though systemic absorption still occurs