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O 2 and subsequently peroxynitrite) by uncoupled eNOS, in turn, enhances the oxidation of BH 4 , creating a vicious circle.[ref] A 2021 study showed that BH2 levels, which indicate increased oxidative stress, increase with age

Here, we introduced the structure and functions of ApoE isoforms, and then we reviewed the potential mechanisms of ApoE4 in the AD pathogenesis, including the effect of ApoE4 on A pathology, and tau phosphorylation, oxidative stress

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