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To separate a phenotype caused by Gpx4 -deficiency from that of Cre side effects, tamoxifen-treated mice harboring Gpx4 fl/fl ;Cre ERT2 and Gpx4 wt/wt ;Cre ERT2 BM cells were allowed to recover and blood was drawn every three weeks (Figure 1)

PMCID: PMC4075452 Griffith O, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

Cell Host Microbe (2017) 22(4):51930 e3

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However, chronic, pathological levels of non-radical ROS in the tumor microenvironment conversely fostered immunosuppression and therapy resistance, highlighting their starkly context-dependent impact [3, 241]