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11 Although low concentrations of PPA may be beneficial, humans with impairments in PPA metabolism (that is, propionic or methymalonic acidemia, holocarboxylase, biotinidase or B12 deficiency, valproate or ethanol exposure) exhibit neurodevelopmental conditions with behavioral and biochemical similarities to ASD

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When coupled with individualized elimination of food triggers, elemental diets reduce the relapse rate of Crohns disease (Jones 1987)