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Mechanistic studies provide molecular explanations: bacterial products can stimulate leukocytes to undergo a respiratory burst, releasing massive amounts of ROS (187, 194)

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80 Animal and human studies have also shown that gut microbiota can be involved in the regulation of chemical signals involved in stress and anxiety (eg, serotonin and cortisol), which implicate a role for probiotics in managing these conditions

Proof-of-concept study on the use of tangerine-derived nanovesicles as siRNA delivery vehicles toward colorectal cancer cell line SW480